Thermo Fisher Scientific Phospho-c-Cbl (Tyr700) Polyclonal Antibody
Phospho-c-Cbl (Tyr700) 폴리클로날 항체로, 인산화된 CBL 단백질을 특이적으로 검출합니다. Western blot과 IHC에 적합하며, 사람·생쥐·랫드 반응성이 있습니다. 고순도 정제 및 안정적 PBS/glycerol 버퍼로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CBL (Accession P22681), corresponding to amino acid residues around phosphorylated Tyr700 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816056 |
Product Specific Information
This antibody detects endogenous levels of CBL only when phosphorylated at Tyr700.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, while other Cbl proteins are ubiquitously expressed.
Like other mammalian Cbl proteins, Cbl-c can ubiquitinate activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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