Thermo Fisher Scientific Phospho-Bim (Ser69) Polyclonal Antibody
인간, 마우스, 랫트에서 Ser69 인산화된 Bim 단백질을 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(Paraffin) 실험에 적합. 고순도 정제 및 안정적인 PBS/glycerol 저장 용액 형태. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5104577
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-Bim (Ser69) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2L11 (Accession O43521), corresponding to amino acid residues around phosphorylated Ser69 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816052 |
Product Specific Information
Antibody detects endogenous levels of Bim only when phosphorylated at Ser69.
Target Information
BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in diverse cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3) and interacts with BCL2, BCL2L1/BCL-X(L), and MCL1, functioning as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting a role in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate that this gene is an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.