Thermo Fisher Scientific KLRG1 Monoclonal Antibody (2F1), Functional Grade, eBioscience
마우스 KLRG1 단백질을 인식하는 시리아 햄스터 유래 단클론 항체(2F1)로서, Flow Cytometry 및 기능적 분석에 적합합니다. 1 mg/mL 액상 형태이며 4°C 보관, Wet ice 배송됩니다. 높은 순도와 낮은 엔도톡신 수준을 유지해 연구용으로 최적화된 제품입니다.
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Thermo Fisher Scientific KLRG1 Monoclonal Antibody (2F1), Functional Grade, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | View 49 publications |
| Functional Assay (Functional) | Assay-Dependent | View 2 publications |
Product Specifications
| Item | Description |
|---|---|
| Published species | Mouse |
| Host / Isotype | Syrian hamster / IgG |
| Recommended Isotype Control | Syrian Hamster IgG Isotype Control, Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F1 |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_2866084 |
Available Conjugates
- Alexa Fluor 488
- Alexa Fluor 532
- Alexa Fluor 561
- Alexa Fluor 647
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395, 496, 563, 615
- Brilliant Violet 421, 480, 605, 711
- eFluor 450, 506
- FITC
- Pacific Orange
- PE, PE-Cyanine5, PE-Cyanine5.5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30–38 kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM).
KLRG1 is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with Ly49 molecules and SHP-1 signaling.
Applications Reported: Flow cytometric analysis and functional assays.
Applications Tested: Tested by flow cytometric analysis of mouse splenocytes at ≤1 µg/test (100 µL final volume).
Cell number should be determined empirically (10⁵–10⁸ cells/test). Titrate for optimal performance.
Storage and Handling: Use in sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: >90% (SDS-PAGE).
Endotoxin Level: <0.001 ng/µg antibody (LAL assay).
Aggregation: <10% (HPLC).
Target Information
KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family containing ITIM motifs in its cytoplasmic domain. These motifs interact with SH2 domains of phosphatases such as SHP-1.
KLRG1 functions as an inhibitory receptor expressed on NK cells and certain T cells, involved in tumor and virus-infected cell lysis and immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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