Thermo Fisher Scientific Insulin Monoclonal Antibody (ICBTACLS), Alexa Fluor 488, eBioscience
인슐린 단백질을 특이적으로 인식하는 Alexa Fluor 488 결합 단일클론 항체로, 사람·마우스·랫트 시료에 반응합니다. 면역조직화학(IHC), 면역세포염색(ICC/IF) 등에 사용되며, 488 nm 형광 특성을 가집니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICBTACLS |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574468 |
Additional Formats
Product Specific Information
This ICBTACLS monoclonal antibody reacts with the hormone insulin, which regulates carbohydrate and fat metabolism. Insulin secretion from pancreatic beta-cells maintains blood glucose levels by promoting glucose uptake and glycogen storage.
Type 1 diabetes results from autoimmune destruction of insulin-producing beta-cells, while type 2 diabetes involves insulin resistance. Insulin also contributes to endothelial function and cognitive processes.
The ICBTACLS antibody recognizes human, mouse, and rat insulin.
Applications Reported: Immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections and microscopy.
Applications Tested: Tested by IHC of formalin-fixed paraffin-embedded tissue using low or high pH antigen retrieval. Recommended ≤ 5 µg/mL; titrate for optimal performance.
Fluorescence Properties:
- Excitation: 488 nm
- Emission: 519 nm
- Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Insulin is a peptide hormone secreted by pancreatic beta cells that regulates carbohydrate, protein, and lipid metabolism. It promotes glucose and amino acid uptake, glycogen storage, triglyceride formation, and protein synthesis.
The mature insulin molecule consists of A and B chains linked by disulfide bonds, derived from proinsulin cleavage.
Insulin deficiency leads to diabetes mellitus and may also be expressed in insulin-producing tumors such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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