Thermo Fisher Scientific Glucagon Monoclonal Antibody (ICACLS), Alexa Fluor 488, eBioscience
Glucagon 단백질을 인식하는 ICACLS 단클론 항체로 Alexa Fluor 488 형광 표지. 인간, 마우스, 랫트 시료에 반응하며 IHC 및 FFPE 조직 염색에 적합. 499/520 nm 형광 특성, 4°C 암소 보관, 연구용 전용.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- 1 publication available
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICACLS |
| Conjugate | Alexa Fluor™ 488 |
| Excitation/Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574454 |
Additional Formats
Product Specific Information
This ICACLS monoclonal antibody reacts with human, mouse, and rat glucagon.
Glucagon is a peptide hormone secreted by pancreatic alpha cells within the islets of Langerhans. It functions as an antagonist to insulin, maintaining blood glucose homeostasis. Glucagon promotes glycogenolysis and gluconeogenesis in the liver. Its secretion is stimulated by hypoglycemia, epinephrine, acetylcholine, and cholecystokinin, and inhibited by insulin and somatostatin. Elevated glucagon levels are observed in pancreatic tumors.
Applications Reported:
- Immunohistochemical staining (IHC)
- IHC of formalin-fixed paraffin-embedded (FFPE) tissue sections
Applications Tested:
- Tested on FFPE human tissue using low pH antigen retrieval
- Recommended concentration ≤10 µg/mL (optimize as needed)
Fluorescence Properties:
- Excitation: 488 nm
- Emission: 519 nm
- Laser: Blue Laser
Filtration:
- 0.2 µm post-manufacturing filtered
Target Information
Glucagon is a 29-residue polypeptide hormone (MW 3482) produced in the pancreas.
A related hormone, enteroglucagon (oxyntomodulin), includes the glucagon sequence extended by 8 residues at the C-terminus.
Biological activities include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis—antagonistic to insulin action, leading to increased blood glucose levels.
Glucagon is localized in pancreatic alpha cells, which make up 15–20% of islet cells, primarily at the islet periphery.
Pathological glucagon overexpression is mainly associated with glucagonomas.
Glucagon-specific antibodies are useful for cell and tumor marker studies via immunohistochemistry and for hormone quantification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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