Thermo Fisher Scientific AR Monoclonal Antibody (OTI3C5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon binding, AR translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is crucial for male reproductive organ development (prostate, epididymis) and functions in nonreproductive tissues such as muscle, hair follicles, and brain.
Abnormalities in AR signaling are associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.