Thermo Fisher Scientific PD-L1 Monoclonal Antibody (OTI1B12), TrueMAB
PD-L1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, 동결건조 형태로 제공됩니다. 종양 면역 회피 연구 및 PD-1/PD-L1 경로 분석에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Full length human recombinant protein of human CD274 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a B7 family member that binds to programmed death receptor 1 (PD-1), negatively regulating T-cell receptor (TCR) signaling.
Upon receptor binding, PD-L1 decreases TCR-mediated proliferation and cytokine production.
PD-L1 expression is abundant in many murine and human cancers and can be upregulated by IFN-gamma stimulation, suggesting its key role in tumor immune evasion.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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