Thermo Fisher Scientific Caspase 10 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL
• Suggested Positive Control: HeLa cell lysate
• Observed Band: ~59 kDa

Product Specifications

Product Specific Information

In Western blot applications, this antibody detects a band at approximately 59 kDa. A suggested positive control is HeLa cell lysate.

Target Information

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small) that dimerize to form the active enzyme.
Caspase-10 cleaves and activates caspases 3 and 7 and is itself processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.