Thermo Fisher Scientific Neurturin Polyclonal Antibody
인간 Neurturin 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. Jurkat lysate를 양성 대조로 사용 가능하며 2–8°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids 178–193 of human Neurturin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155422 |
Product Specific Information
- Detects a band at approximately 14 kDa in Western blot.
- Suggested positive control: Jurkat cell lysate.
- Compatible blocking peptide: PEP-0005.
Target Information
Glial cell line-derived neurotrophic factor (GDNF) plays key roles in neuron survival and differentiation. Neurturin (NTN), a novel neurotrophic factor cloned from human and mouse, requires receptor tyrosine kinase RET and glycosylphosphatidylinositol-linked receptor NTNRα for physiological responses. NTN binds with GFR-α2 and RET PTK to activate the RET receptor tyrosine kinase pathway. Both NTN and GDNF activate MAP kinase and PI3-kinase pathways, essential for neuronal development. Neurturin and GDNF define a new family of neurotrophic factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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