Thermo Fisher Scientific ADAM17 Polyclonal Antibody
ADAM17 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot 및 Immunocytochemistry에 사용 가능. 인간 및 랫트 반응성, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 2–8°C 보관 권장, 장기 보관 시 -20°C.
- 카탈로그번호
- PA519872
- 판매단위
- pk
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Thermo Fisher Scientific ADAM17 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the carboxy terminus of human TACE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153365 |
Product Specific Information
- Suggested positive control: HeLa cell lysate
- Immunogen located within the last 50 amino acids of TACE
- Predicted molecular weight: ~93 kDa
- Observed band in Western blot: 93–125 kDa (Post-modification: 9 N-linked glycosylation)
- Predicted species reactivity based on immunogen sequence: Mouse (94.1%)
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It mediates proteolytic release of several cell-surface proteins, including:
- p75 TNF-receptor
- Interleukin receptor type II
- p55 TNF-receptor
- Transforming growth factor-alpha
- L-selectin
- Growth hormone receptor
- MUC1
- Amyloid precursor protein
ADAM17 acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the gene can result in inflammatory skin and bowel disease (neonatal type 1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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