Thermo Fisher Scientific CD22 Monoclonal Antibody (MEM-01), PE
CD22 단백질을 인식하는 마우스 단클론 항체로, PE 형광체로 결합되어 흐름세포분석(Flow Cytometry)에 적합합니다. 인간 및 비인간 영장류 시료에 반응하며, Raji 세포주 유래 항원을 사용했습니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 20 µL/100 µL whole blood
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-01 |
| Immunogen | Burkitt’s lymphoma cell line Raji |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071685 |
Additional Formats
- Unconjugated: MA1-19189
- Biotin: MA1-19507
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes a unique epitope "E" and does not cross-block antibodies RFB-4, CLB22/1, and CLB-BLy1.
Target Information
CD22 (BL-CAM) is a type 1 integral membrane glycoprotein (130–140 kDa) expressed in both cytoplasm and cell membrane of B-lymphocytes.
It appears early in B-cell differentiation, similar to CD19, and is mainly expressed in mature B cells (CD22+) but not in plasma cells (CD22−).
CD22 is strongly expressed in hairy cell leukemia and is also positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
It binds preferentially to α2,6-linked sialic acid and plays a role in regulating B-cell antigen receptor signaling through tyrosine phosphorylation and interaction with Src family kinases and phosphatases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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