Thermo Fisher Scientific beta-2 Microglobulin Monoclonal Antibody (B2M-01), PE
인간 beta-2 microglobulin을 인식하는 단클론 항체로, PE 형광표지되어 Flow Cytometry에 적합합니다. B2M-01 클론이며, 고순도 정제된 형태로 제공됩니다. 사람 시료 특이적이며 다른 종과 교차반응하지 않습니다.
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Thermo Fisher Scientific beta-2 Microglobulin Monoclonal Antibody (B2M-01), PE
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–2 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B2M-01 |
| Immunogen | Purified human beta-2 microglobulin |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2258924 |
Additional Formats
- Unconjugated (MA1-19141)
- Alexa Fluor 647 (MA5-18119)
- Biotin (MA1-19506)
- FITC (MA1-19579)
- HRP (MA1-19679)
- Custom conjugation available on request
Product Specific Information
This antibody reacts with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig-like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.
It does not cross-react with mouse, rabbit, canine, chicken, or bovine.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms a subunit of MHC class I. It is expressed on various human cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes.
B2M is homologous to immunoglobulin constant regions and has a beta-pleated sheet structure. It is involved in antigen processing and presentation, TCR signaling, and CD8+ cell activation.
Encoded by the B2M gene on chromosome 15, mutations can cause hypercatabolic hypoproteinemia. Beta-2 microglobulin levels are used to assess renal function and serve as a prognostic marker in HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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