Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), PE
CD59 단백질을 인식하는 인간 반응성 Mouse IgG2a 단일클론 항체로, PE 형광 표지되어 흐름세포분석(Flow Cytometry)에 적합합니다. CD59의 명확한 에피토프(W40, R53)에 결합하며 차단(blocking) 기능을 가집니다. 연구용으로만 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL/100 µL whole blood
- Publications: View 2 publications
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-43 |
| Immunogen | Thymocytes and T lymphocytes |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073165 |
Additional Formats
- Unconjugated
- Alexa Fluor 647
- APC
- Biotin
- FITC
- Request custom conjugation
Product Specific Information
This antibody reacts with well-defined epitope (W40, R53) on CD59 (Protectin), an 18–20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on the surface of all hematopoietic cells. It is widely present on cells in all tissues. This antibody does not compete with MEM-43/5 and exhibits blocking activity.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC). It preserves autologous cells from complement-mediated lysis by binding complement C8 and/or C9 during MAC assembly, preventing pore formation. CD59 also functions as a low-affinity ligand for CD2, contributing to T-cell costimulation and signal transduction. Mutations in CD59 cause CD59 deficiency, leading to hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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