Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (MEM-75), PE
인간 CD71(Transferrin Receptor)을 인식하는 Mouse IgG1 단일클론 항체로, PE 형광체로 결합되어 Flow Cytometry에 적합합니다. 활성 림프구 및 조혈계 세포 분석에 유용하며, 4°C 암소 보관이 권장됩니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-75 |
| Immunogen | Pre-B cell line NALM-6 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073345 |
Additional Formats
- Unconjugated (MA1-19137)
- Alexa Fluor 647 (MA5-18151)
- Alexa Fluor 700 (MA5-28599)
- APC (MA1-19789)
- Biotin (MA1-19505)
- FITC (MA1-19577)
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages, and erythroid precursors. Expression is lost on resting blood leukocytes.
The antibody MEM-75 does not block binding of transferrin to its receptor.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Acidification within endosomes leads to iron release, and the apotransferrin-receptor complex is recycled to the cell surface. The transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) levels serve as a diagnostic indicator for anemia and erythropoietin (EPO) misuse detection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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