Thermo Fisher Scientific DUX4 Monoclonal Antibody (P4H2)
Thermo Fisher Scientific의 DUX4 단클론 항체(P4H2)는 인간 DUX4 단백질을 인식하며 Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Protein G로 정제된 액상 항체로, PBS에 0.02% sodium azide를 포함하며 4°C 또는 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2.0 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | - |
| ELISA | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | P4H2 |
| Immunogen | Synthetic peptide corresponding to the C-terminal of human DUX4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_11152574 |
Target Information
DUX4 (Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies.
FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4.
DUX4 expression is epigenetically suppressed in differentiated tissues, and residual transcripts are spliced to remove the carboxyterminal domain associated with cell toxicity. In FSHD individuals, expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues, resulting in a small percentage of cells expressing relatively abundant amounts of full-length DUX4 mRNA and protein.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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