Thermo Fisher Scientific OPA1 Monoclonal Antibody (1E8-1D9)
OPA1 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 등 다양한 종에 반응하며, 단백질 G 정제 및 액상 형태로 제공됩니다. 미토콘드리아 형태 유지 및 OPA1 연구용에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:50 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Hamster, Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E8-1D9 |
| Immunogen | Human OPA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153569 |
Product Specific Information
In Western blot, multiple protein isoforms can be seen at approximately 90, 80, and 65 kDa.
Target Information
OPA1 is a dynamin-related GTPase critical for maintaining mitochondrial morphology and mtDNA. Mutations in OPA1 are associated with heterozygous optic atrophy, a dominant trait leading to reduced visual clarity and potential blindness. The disease typically begins in childhood and progresses over time due to optic nerve fiber degeneration. OPA1 dysfunction has also been linked to schizophrenia characteristics through mitochondrial network disruption, affecting apoptosis and cellular metabolic regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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