Thermo Fisher Scientific TBK1 Monoclonal Antibody (108A429)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Suggested positive control: human testis protein, NIH-3T3 or RAW.

Target Information

TBK1 (TANK-binding kinase 1) is a serine/threonine kinase belonging to the IKK family, involved in NF-κB activation and IRF3 signaling. It acts as a key mediator of gene expression during immune and inflammatory responses. NF-κB activity is regulated by IKB proteins, which are degraded upon phosphorylation by the IKK complex, leading to NF-κB activation. The IKK complex includes IKKa, IKKβ, and IKKK. TBK1, also known as NAK or T2K, activates IKKβ through direct phosphorylation and mediates NF-κB activation in response to growth factors and PMA. TBK1 functions upstream of NIK and the IKK complex and plays a critical role in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.