Thermo Fisher Scientific TBK1 Monoclonal Antibody (108A429)
TBK1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 108A429). Western blot, IHC, ICC, IP에 사용 가능. NF-κB 및 IRF3 신호전달 연구에 적합. 고순도 Protein G 정제, 안정적 액상 형태로 제공.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 |
| Immunocytochemistry (ICC/IF) | 1:20 |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 108A429 |
| Immunogen | Synthetic peptide (YYQFKKDKAERRLAYC) of TBK1/NAK protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537678 |
Product Specific Information
Suggested positive control: human testis protein, NIH-3T3 or RAW.
Target Information
TBK1 (TANK-binding kinase 1) is a serine/threonine kinase belonging to the IKK family, involved in NF-κB activation and IRF3 signaling. It acts as a key mediator of gene expression during immune and inflammatory responses. NF-κB activity is regulated by IKB proteins, which are degraded upon phosphorylation by the IKK complex, leading to NF-κB activation. The IKK complex includes IKKa, IKKβ, and IKKK. TBK1, also known as NAK or T2K, activates IKKβ through direct phosphorylation and mediates NF-κB activation in response to growth factors and PMA. TBK1 functions upstream of NIK and the IKK complex and plays a critical role in protecting embryonic liver from apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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