Thermo Fisher Scientific Phospho-Fra1 (Ser265) Polyclonal Antibody

Thermo Fisher Scientific Phospho-Fra1 (Ser265) Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of FRA1 only when phosphorylated at Ser265.

Target Information

The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1, and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by various agents and function as transcriptional regulators for several genes.
Unlike c-Jun proteins, which form homo- and heterodimers binding to specific DNA response elements, c-Fos proteins are active only as heterodimers with Jun family members. Selected ATF/CREB family members can also form leucine zipper dimers with Fos and Jun, exhibiting differential specificity and affinity for AP-1 and CRE sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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