Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8)
닭 CD8α 항원을 인식하는 Mouse IgG1 단클론 항체로 면역조직화학(IHC) 및 유세포분석(Flow Cytometry)에 사용 가능. 비접합(Unconjugated) 형태이며 다양한 형광 접합 버전 제공. 0.5 mg/mL 농도로 정제된 액상 제품으로 4°C에서 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-Dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-8 |
| Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745688 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a crucial role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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