Thermo Fisher Scientific Phospho-PDGFRB (Tyr740) Monoclonal Antibody (J.541.8)
인간 및 생쥐 PDGFRB (Tyr740) 인산화 형태를 검출하는 Rabbit 단일클론 항체로 Western blot에 적합합니다. 고순도 Affinity chromatography로 정제되었으며 액상 형태로 제공됩니다. 세포 신호전달 및 암 연구용으로 활용됩니다.
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- MA515144
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- pk
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Thermo Fisher Scientific Phospho-PDGFRB (Tyr740) Monoclonal Antibody (J.541.8)
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.541.8 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr740 of human PDGF receptor ß |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10978180 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
PDGFRB is a receptor tyrosine kinase involved in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal cells. The receptor composition—either homodimer or heterodimer—depends on the bound growth factor.
The PDGFRB gene is located on chromosome 5 near genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all possibly related to the 5-q syndrome.
A translocation between chromosomes 5 and 12 (PDGFRB and ETV6) can lead to chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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