Thermo Fisher Scientific Bcl-xL Monoclonal Antibody (C.85.1)
Bcl-xL 단백질을 인식하는 Rabbit Monoclonal Antibody (Clone C.85.1). Western blot, IHC, ICC, Flow cytometry, IP에 적합. 인간, 마우스, 원숭이, 랫트 반응성. 고순도 Affinity chromatography 정제, 비접합 액상 형태.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:600–1:2400 |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 |
| Flow Cytometry (Flow) | 1:200–1:800 |
| Immunoprecipitation (IP) | 1:100 |
View 8 publications related to this antibody.
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.85.1 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 144 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979212 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other Bcl-2 family members.
Target Information
BCL-XL is a member of the BCL-2 protein family, forming hetero- or homodimers that regulate apoptosis. It is located at the outer mitochondrial membrane and influences VDAC opening, which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release—key steps in apoptosis induction. Two splice variants exist: the longer isoform inhibits apoptosis, while the shorter isoform activates it.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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