Thermo Fisher Scientific Bax Recombinant Rabbit Monoclonal Antibody (SZ3-07)

Applications

Western Blot (WB)

• Tested Dilution: 1:20,000
• View 5 publications

Flow Cytometry (Flow)

• Tested Dilution: 1:1,000
• View publications

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

BAX is a member of the Bcl-2 family and plays a crucial role in apoptosis regulation.

• Bcl-2: anti-apoptotic
• BAX: pro-apoptotic

Apoptosis regulation involves homo- and heterodimerization of BAX and Bcl-2 isoforms.

• Bax α (21 kDa) and Bax β (24 kDa) contain BH1, BH2, BH3 domains
• Bax β lacks a hydrophobic transmembrane domain
• Bcl-2 α (26 kDa) and Bcl-2 β (22 kDa) differ in UTR and coding regions

Overexpression of BAX promotes cell death through dimerization with BCL-2 related proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.