Thermo Fisher Scientific SATB1 Recombinant Rabbit Monoclonal Antibody (SP05-03)
SATB1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, Flow Cytometry에 적합하며 높은 특이성과 재현성을 제공. 단백질 A로 정제된 액상 형태로, 장기 보관 시 -20°C에서 안정적으로 유지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SP05-03 |
| Immunogen | Synthetic peptide within Human SATB1 (aa 5–54) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809328 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by clone screening to select optimal candidates.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
SATB1 (DNA-binding protein SATB1) is a key silencing factor involved in the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. It binds to AT-rich DNA sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA.
SATB1 functions as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner. It modulates genes essential for T-cell CD8SP maturation and provides chromatin contexts preferentially targeted by HIV-1 integration machinery. HIV-1 Tat can overcome SATB1-mediated repression of IL1 and IL2RA by binding to the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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