Thermo Fisher Scientific BCL-XL Recombinant Rabbit Monoclonal Antibody (SZ3-03)
Thermo Fisher BCL-XL Recombinant Rabbit Monoclonal Antibody (SZ3-03)는 인간, 마우스, 랫트 반응성을 가지며, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. 높은 특이성과 민감도를 제공하며, 일관된 로트 간 품질을 보장합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SZ3-03 |
| Immunogen | Synthetic peptide within Human Bcl-XL aa 37–86 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809323 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
BCL-XL belongs to the BCL-2 protein family, which regulates apoptosis through hetero- or homodimer formation. It is located at the outer mitochondrial membrane and modulates VDAC channel opening, influencing mitochondrial potential, reactive oxygen species production, and cytochrome C release.
Two alternatively spliced transcript variants exist:
- Long isoform: apoptotic inhibitor
- Short isoform: apoptotic activator
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-32029_BCL-XL_Q07817-1_Rabbit.svg, MA5-32029_BCL-XL_Q07817-1_Rabbit_PDP.jpeg)
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