Thermo Fisher Scientific SATB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Store as a concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze–thaw cycles.

Target Information

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
It functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing local chromatin-loop remodeling.
SATB2 also serves as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
It is required for the initiation of upper-layer neuron-specific genetic programs and repression of deep-layer neuron genes, likely by modulating BCL11B expression.
Mutations in SATB2 are associated with cleft palate isolated (CPI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.