Thermo Fisher Scientific SIRT1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store as a concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, add 50% glycerol, aliquot, and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through deacetylation of histones and can promote alterations in histone and DNA methylation, leading to transcriptional repression.
It is essential in skeletal muscle cell differentiation and mediates inhibitory effects on myoblast differentiation under low nutrient conditions involving AMPK and NAMPT pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.