Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Caspase-12 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 적합하며, 인간·마우스·랫트 시료에서 반응. ER 스트레스 관련 세포사멸 연구에 활용 가능.
- 카탈로그번호
- PA520033
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 16 amino acids within the large cleavage product of murine caspase-12 (amino acids 170–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152584 |
Product Specific Information
- Suggested positive controls: human heart, mouse heart, or rat heart tissue lysates
- PA5-20033 can be used with blocking peptide PEP-0152
- Caspase-12 antibody is predicted to have no cross-reactivity with other members of the caspase family
Target Information
Caspase-12 is involved in the endoplasmic reticulum (ER) stress-induced apoptosis pathway, distinct from the death receptor and mitochondrial pathways mediated by caspase-8 and caspase-9. It is localized to the ER, activated by ER stress such as calcium homeostasis disruption, and mediates ER stress-induced cell death.
Caspase-12 is co-localized in the ER with proteins related to Alzheimer’s disease, including γ-secretase presenilin and β-amyloid precursor protein (APP), and mediates cytotoxicity induced by amyloid-beta. It is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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