Thermo Fisher Scientific PHAP Polyclonal Antibody
PHAP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 1 µg/mL로 최적화. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 세포사멸 연구용으로 적합.
- 카탈로그번호
- PA520024
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids at amino terminus of human PHAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154184 |
Product Specific Information
- Suggested positive control: Raji cell lysate
- PA5-20024 can be used with blocking peptide PEP-0143
Target Information
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after being released from mitochondria, binds to Apaf-1, forming an apoptosome that activates procaspase-9. Activated caspase-9 then triggers effector caspases (caspase-3, -6, and -7), which cleave key proteins in apoptosis.
PHAPs (putative HLA-DR-associated proteins) are important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation and stimulates the mitochondrial apoptotic pathway. It also opposes Ras- and Myc-mediated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-20024_PHAP_P39687-1_Rabbit.svg
- PA5-20024_PHAP_P39687-1_Rabbit_PDP.jpeg
- PA5-20024_PHAP_Q92688-1_Rabbit.svg
- PA5-20024_PHAP_Q92688-1_Rabbit_PDP.jpeg
- PA5-20024_PHAP_Q9BTT0-1_Rabbit.svg
- PA5-20024_PHAP_Q9BTT0-1_Rabbit_PDP.jpeg
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