Thermo Fisher Scientific SAPAP3 Polyclonal Antibody
SAPAP3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간, 마우스, 랫트 시료에 반응하며 WB 및 IHC에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, 신경세포 시냅스 연구에 유용.
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Thermo Fisher Scientific SAPAP3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the carboxy terminus of human SAPAP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156625 |
Product Specific Information
- Suggested positive control: rat brain tissue lysate
- PA5-20465 can be used with blocking peptide PEP-0582.
Target Information
SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family that interacts specifically with PSD-95/SAP90, a membrane-associated guanylate kinase localized at the postsynaptic density (PSD) in neuronal cells.
SAPAP3 acts as an adaptor protein connecting synaptic scaffolding proteins, cytoskeletal elements, and signaling molecules such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).
Both SAPAP3 protein and mRNA are localized to dendrites, whereas SAPAP1, -2, and -4 mRNAs are mainly detected in cell bodies.
Research suggests SAPAP3 may play a role in obsessive-compulsive disorder (OCD); mice lacking SAPAP3 exhibit OCD-like behaviors that can be rescued by selective SAPAP3 expression in the striatum.
At least two isoforms of SAPAP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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