Thermo Fisher Scientific SP110 Polyclonal Antibody
SP110 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며 1 mg/mL 농도의 액상 형태입니다. 항원 친화 크로마토그래피로 정제되었으며 PBS buffer에 sodium azide가 포함되어 있습니다. 냉장 보관 권장.
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Thermo Fisher Scientific SP110 Polyclonal Antibody
Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the amino terminus of the human IPR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154064 |
Product Specific Information
- A suggested positive control is SW480 cell lysate.
- PA5-20461 can be used with blocking peptide PEP-0578.
Target Information
Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component.
The protein functions as a gene transcription activator and may serve as a nuclear hormone receptor coactivator.
Alternative splicing has been observed, and three transcript variants encoding distinct isoforms have been identified.
SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/SP110 gene product may integrate signals from intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis.
IPR1/SP110 is upregulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.
Defects in SP110 cause severely impaired resistance to M. tuberculosis infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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