Thermo Fisher Scientific DFNA5 Monoclonal Antibody (1E10)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Concentration: 3 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SQSSFGTLRK QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC GGIVGIQTKT VQVSATEDGN

Target Information

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung, and pancreas. It exists as two alternatively spliced isoforms (short and long).
Defects in the DFNA5 gene cause non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of hearing loss resulting from damage to sound-processing structures in the brain.
The DFNA5 gene maps to human chromosome 7, which contains over 1,000 genes (~5% of the human genome). Mutations in chromosome 7 genes have been associated with Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.