Thermo Fisher Scientific ROR2 Monoclonal Antibody (OTI5F8), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. It plays a role in early chondrocyte formation, cartilage, and growth plate development.
This protein is highly expressed during early embryogenesis, decreases significantly by day 16, and is minimally expressed in adult tissues.

Mutations in ROR2 are associated with:

• Brachydactyly type B1 (BDB1): Autosomal dominant skeletal disorder with hypoplasia/aplasia of distal phalanges and nails, affecting both fingers and toes.
• Robinow syndrome (RRS): Autosomal recessive disorder characterized by skeletal dysplasia, limb shortening, spinal defects, and distinctive facial features.

The protein includes:

• 1 Frizzled (FZ) domain
• 1 Immunoglobulin-like C2-type domain
• 1 Kringle domain

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.