Thermo Fisher Scientific ROR2 Monoclonal Antibody (OTI5E3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors.
It is involved in early chondrocyte and cartilage formation and growth plate development. Expression is high during early embryonic development, decreasing significantly by day 16 and remaining low in adult tissues.

Defects in ROR2 are associated with:

• Brachydactyly type B1 (BDB1): Autosomal dominant skeletal disorder with hypoplasia/aplasia of distal phalanges and nails.
• Robinow syndrome (RRS): Autosomal recessive disorder characterized by skeletal dysplasia, limb bone shortening, spine defects, brachydactyly, and facial dysmorphism.

The ROR2 protein contains:

• 1 frizzled (FZ) domain
• 1 immunoglobulin-like C2-type domain
• 1 kringle domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.