Thermo Fisher Scientific ROR2 Monoclonal Antibody (OTI3F8), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:250

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. It plays a role in early chondrocyte formation, cartilage and growth plate development.
High expression is observed during early embryonic development, decreasing significantly by day 16 and remaining low in adult tissues.
Defects in ROR2 are associated with:

• Brachydactyly type B1 (BDB1): autosomal dominant skeletal disorder causing hypoplasia/aplasia of distal phalanges and nails.
• Robinow syndrome (RRS): autosomal recessive disorder characterized by skeletal dysplasia, limb bone shortening, spinal defects, and facial dysmorphism.

The protein contains:

• 1 frizzled (FZ) domain
• 1 immunoglobulin-like C2-type domain
• 1 kringle domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.