Thermo Fisher Scientific Cytokeratin 14 (KRT14) (Squamous Cell Marker) Recombinant Rabbit Monoclonal Antibody (KRT14/4584R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

Cytokeratins (CK) are intermediate filaments of epithelial cells, found in both keratinizing tissues (e.g., skin) and non-keratinizing cells (e.g., mesothelial cells). At least 20 different CKs have been identified, generally classified into two groups: type I (acidic polypeptides) and type II (basic polypeptides).
Keratin 14, a type I low molecular weight keratin, pairs with keratin 5 and serves as a distinguishing marker for stratified epithelial cells versus simple epithelial cells. It is valuable in identifying squamous cell carcinomas and is considered a prognostic marker in breast carcinomas. All epithelial cells express at least one acidic and one basic cytokeratin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.