Thermo Fisher Scientific CaBP8 Polyclonal Antibody
CaBP8 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체입니다. 인간, 생쥐, 랫트 반응성이 있으며 Western blot에 최적화되어 있습니다. 액상 형태로 제공되며 항원 친화 크로마토그래피로 정제되었습니다. 세포 신호전달 연구에 적합합니다.
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Thermo Fisher Scientific CaBP8 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the amino terminus of human CaBP8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154805 |
Product Specific Information
- Suggested positive control: NIH-3T3 cell lysate
- PA5-21002 can be used with blocking peptide PEP-1116
Target Information
Calcium binding proteins (CaBP) play a crucial role in calcium-mediated cellular signal transduction in the central nervous system. The CaBP family shares high similarity with calmodulin (CaM I), and CaBP proteins can functionally substitute or augment CaM I activity.
CaBP8 contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP8 and CaBP7 possess unique targeting mechanisms among CaBPs, contributing to differential Ca²⁺ sensing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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