Thermo Fisher Scientific p48 DDB2 Polyclonal Antibody
Human DDB2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등 다양한 응용에 사용 가능. 합성 펩타이드(aa 419-427)로 면역화. 비결합형 액상 형태로 제공되며, -20°C에서 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- 100-401-A10
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p48 DDB2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 419–427 of Human DDB2 (C-terminal) coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 85 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
- Reacts with human DDB2; cross-reactivity with other species is not known.
Target Information
Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48 (DDB1 and DDB2, respectively). The DDB heterodimer participates in repairing DNA damaged by ultraviolet light. Also known as UV-DDB, XPE-BF, or XAP-1, it binds to UV-induced cyclobutane pyrimidine dimers (CPDs).
Mutations in the DDB2 gene are associated with xeroderma pigmentosum group E (XPE), an autosomal recessive disorder characterized by defective nucleotide excision repair, hypersensitivity to sunlight, and increased skin cancer risk. The hepatitis B virus X protein interacts with DDB1, potentially mediating HBx transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.