Thermo Fisher Scientific PARC Polyclonal Antibody

Thermo Fisher Scientific PARC Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Reacts with human and mouse PARC; cross-reactivity with other species is not known.

Target Information

PARC (Parkin-like ubiquitin ligase) acts as a cytoplasmic anchor for p53-associated protein complexes. Inactivation of PARC leads to nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression promotes cytoplasmic sequestration of p53. PARC knockout mice are viable without obvious phenotype, suggesting functional redundancy with other cullin family E3 ubiquitin ligases. p53 binding to PARC may regulate PARC function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.