Thermo Fisher Scientific IL-13 Monoclonal Antibody (85BRD), FITC, eBioscience
인간 IL-13을 표적하는 85BRD 단클론 항체로, FITC 형광 표지되어 있습니다. Flow Cytometry용으로 최적화되어 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific IL-13 Monoclonal Antibody (85BRD), FITC, eBioscience
Applications
- Flow Cytometry (intracellular staining)
Tested Dilution: 5 µL (0.25 µg)/test
Publications: View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Nematode |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 85BRD |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572514 |
Available Formats
- Alexa Fluor 647
- APC
- eFluor 450
- PE
- PE-Cyanine7
- Request custom conjugation
Product Specific Information
The 85BRD monoclonal antibody reacts with human interleukin-13 (IL-13). IL-13 (NC30) is a 12.5 kDa protein secreted by activated T helper cells, CD8+ T cells, and NK cells.
Biological activities include:
- Suppression of macrophage cytotoxic activity
- Upregulation of IL-1RA expression
- Suppression of inflammatory cytokine expression
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and validated using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and BestProtocols® Protocol A: Two-step protocol for cytoplasmic proteins.
Use at 5 µL (0.25 µg) per test.
A test is defined as the amount of antibody that stains a cell sample in a final volume of 100 µL (typically 10⁵–10⁸ cells/test).
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-13 is an immunoregulatory cytokine produced by activated Th2 cells, regulating inflammatory and immune responses.
Functions include:
- Down-regulation of macrophage activity
- Inhibition of pro-inflammatory cytokine and chemokine production
- Involvement in allergen-induced asthma (IgE-independent mechanism)
- Regulation of B cell maturation and differentiation
- Up-regulation of CD23 and MHC class II expression
- Promotion of IgE isotype switching
Structurally, IL-13 resembles IL-3, IL-4, IL-5, and GM-CSF.
The IL-13 gene is part of a cytokine gene cluster on chromosome 5q, closely located near IL4.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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