Thermo Fisher Scientific HMBS Polyclonal Antibody
HMBS 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 40% 글리세롤과 0.02% sodium azide를 포함합니다. 인체 반응성으로 연구용에만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HMBS. Recombinant protein control fragment (Product #RP-89537). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642471 |
Product Specific Information
Immunogen sequence:
EFSAIILATA GLQRMGWHNR VGQILHPEEC MYAVGQGALG VEVRAKDQDI LDLVGVLHDP ETLLRCIAER AFLRHLEGGC SVPVAVHTAM KDGQLYLTGG VWSLDGSDSI QETMQATIHV PAQHEDGPED DPQLV
Ortholog sequence identity:
- Mouse: 93%
- Rat: 94%
Target Information
PBGD (porphobilinogen deaminase), also known as hydroxymethylbilane synthase (HMBS), is a cytoplasmic enzyme involved in the heme synthesis pathway. It belongs to the HMBS family. Deficiency of PBGD results in impaired pyrrole metabolism, leading to the inherited disorder acute intermittent porphyria (AIP).
AIP is characterized by acute neurological attacks with hypertension, tachycardia, peripheral neuropathy, abdominal pain, and elevated urinary aminolevulinic acid and porphobilinogen levels.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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