Thermo Fisher Scientific TTYH1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TTYH1. Recombinant protein control fragment (Product #RP-103083). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TTYH1,uniProtId:Q9H313-1,ncbiNodeId:9606,antigenRange:272-381,antigenLength:450,antigenImageFileName:PA5-62229_TTYH1_Q9H313-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62229_TTYH1_Q9H313-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649108

Product Specific Information

Immunogen sequence: SDFCSNPDPY VLNLTQEETG LSSDILSYYL LCNRAVSNPF QQRLTLSQRA LANIHSQLLG LEREAVPQFP SAQKPLLSLE ETLNVTEGNF HQLVALLHCR SLHKDYGAAL

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.

Target Information

TTYH1 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH1 is a Ca2+-independent, volume-sensitive large conductance chloride (Cl-) channel. TTYH1 is primarily expressed in neural tissue and upregulated in astrocytoma, glioma, and several other cancers. Recent experiments have shown that TTYH1 is an integral endoplasmic reticulum (ER) membrane protein involved in cell proliferation and is thought to play an essential role in embryonic cell growth, possibly through the Ca2+ storage/release process in ER membranes during early development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.