Thermo Fisher Scientific Leptin Receptor Recombinant Rabbit Monoclonal Antibody (ARC0454)
Leptin Receptor를 인식하는 Rabbit Recombinant Monoclonal Antibody로 Western blot, IHC, ELISA에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity 정제, PBS/glycerol buffer 보존. -20°C에서 안정적 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0454 |
| Immunogen | Synthetic peptide corresponding to amino acids 1000–1100 of human Leptin Receptor (UniProt ID: P48357) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849150 |
Product Specific Information
Immunogen sequence:
EEQGLINSSV TKCFSSKNSP LKDSFSNSSW EIEAQAFFIL SDQHPNIISP HLTFSEGLDE LLKLEGNFPE ENNDKKSIYY LGVTSIKKRE SGVLLTDKSR V
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays a critical role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of OB-R by leptin triggers downstream signaling via the JAK/STAT pathway. OB-R can dimerize extracellularly, and intracellular domain dimerization initiates signaling. Multiple isoforms exist with differing signaling capacities. The long form of OB-R is expressed in the choroid plexus and hypothalamus, regions associated with satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and altered CNS activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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