Thermo Fisher Scientific PHKB Polyclonal Antibody
인간 PHKB 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS·글리세롤 버퍼에 보존됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PHKB (Recombinant protein control fragment, Product #RP-107926) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664315 |
Product Specific Information
Immunogen sequence:
AALEAINGFNL FGNQGCSWSV IFVDLDAHNR NRQTLCSLLP RESRSHNTDA ALLPCISYPA FALDDEVLFS QTLDKVVRKL KGKYGFKRFL RDGYRT
Highest antigen sequence identity to orthologs:
- Mouse: 98%
- Rat: 97%
Target Information
Phosphorylase kinase is a hexadecameric enzyme composed of four copies of four subunits encoded by PHKA, PHKB, PHKG, and PHKD genes. This serine/threonine-specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, facilitating glucose-1-phosphate release from glycogen.
PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid subunit with regulatory functions controlled by phosphorylation.
Mutations in PHKB cause glycogen storage disease type 9B, characterized by mild hepatomegaly, slightly elevated transaminase and plasma lipids, no muscle involvement, and gradual improvement with age.
There are four isoforms of PHKB produced by alternative splicing events.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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