Thermo Fisher Scientific beta Arrestin 1 Polyclonal Antibody
Beta Arrestin 1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, Flow Cytometry에 사용 가능. Human에 반응하며, sequence homology 기반으로 bovine, mouse, rat, rabbit에도 반응 예측. Protein A 및 항원 친화 크로마토그래피로 정제됨.
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- PA535089
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between amino acids 336–363 from the C-terminal region of human ARRB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552399 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, rat, and rabbit based on sequence homology.
Target Information
Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. It functions as an adaptor or scaffold molecule essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G protein–coupled receptors (GPCRs). After ligand binding and interaction with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1/2 on serine 412 in a negative feedback mechanism and binds to phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated, and the GPCRs are internalized, leading to activation of the Ras–Raf–ERK signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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