Thermo Fisher Scientific SMAD4 Polyclonal Antibody
SMAD4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성 검증 완료. 고순도 항원 친화 크로마토그래피 정제, 안정적 액상 형태로 4°C 또는 -20°C 보관 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 322–552 of SMAD4 (Uniprot ID: Q13485) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552158 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2, DDDDK-tagged SMAD4-transfected 293T.
- Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. Also known as Smad family member 4, MAD homolog 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains N-terminal MH1 and C-terminal MH2 domains involved in DNA binding and protein interactions.
Upon TGF-β or BMP ligand binding, receptor phosphorylation activates R-Smads (1, 2, 3, 5, 8), which form complexes with Smad4 and translocate to the nucleus.
Smad4 functions as a tumor suppressor by regulating genes such as Cyclin D1 (downregulated) and collagen (upregulated), affecting cell proliferation.
Dephosphorylation controls nuclear export and Smad nucleocytoplasmic dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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