Thermo Fisher Scientific RIP2 Polyclonal Antibody
RIP2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC에 사용 가능. 인간 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. RIPK2 신호전달 연구에 적합하며 연구용으로만 사용.
- 카탈로그번호
- PA534808
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 333–540 of RIP2 (Uniprot ID: O43353) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.87 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552160 |
Product Specific Information
- Recommended positive controls: HeLa, Molt-4
- Predicted reactivity: Rat (80%), Bovine (82%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RIPK2 is a serine/threonine kinase involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through CARD-CARD domains. It contributes to tyrosine phosphorylation of ARHGEF2 via Src kinase, leading to NF-kappaB activation. RIPK2 undergoes autophosphorylation and Lys-63-linked polyubiquitination by E3 ligases XIAP, BIRC2, and BIRC3, facilitating MAP3K7/TAK1 recruitment and NF-kappaB activation. This signaling cascade regulates immune response, growth control, and apoptosis protection. RIPK2 also participates in T-cell receptor engagement, promoting BCL10 phosphorylation and NF-kappaB activation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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