Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (3C11), APC
Alpha Synuclein 단백질 검출용 APC 결합 단일클론 항체로, 인간·생쥐·랫드 시료에 반응합니다. WB, ICC/IF, ELISA, Dot blot에 사용 가능하며, 고순도 Protein G 정제 및 1 mg/mL 농도의 액상 제형입니다. 파킨슨병 및 신경퇴행성 질환 연구에 적합합니다.
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Thermo Fisher Scientific Alpha Synuclein Monoclonal Antibody (3C11), APC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1:1,000 |
| Dot blot (DB) | 1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C11 |
| Immunogen | Human alpha synuclein monomer (target family: alpha Synuclein, UniProt ID: P37840-1, antigen range: 1–140) |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic), Wet ice (international) |
| RRID | AB_2932291 |
Additional Formats
- FITC conjugate: MA5-45838
- PerCP conjugate: MA5-45839
- Custom conjugation available upon request
Product Specific Information
- A 1:1,000 dilution of MA5-45837 detects Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- Binds within the 81–130 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides.
- Detects approximately 14 kDa band corresponding to Alpha Synuclein; a band at approximately 30 kDa represents a dimer.
Target Information
Alpha-synuclein is a member of the synuclein family, including beta- and gamma-synuclein. These proteins are abundant in the brain and regulate synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene encoding alpha-synuclein are implicated in Parkinson’s disease. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
Associated diseases include Parkinson Disease 1 (Autosomal Dominant) and Dementia with Lewy Bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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