Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (10H7), FITC
FITC로 표지된 alpha Synuclein 단클론 항체(10H7)로 인간, 마우스, 랫트 시료에 반응. WB, ICC/IF, ELISA, Dot blot에 적합. 498/517 nm 형광 특성. 단백질 G 정제, 보존제 무첨가, 4°C 암소 보관.
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Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (10H7), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1:1,000 |
| Dot blot (DB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10H7 |
| Immunogen | Mouse alpha synuclein aggregate |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932295 |
Additional Formats
- APC (Cat. MA5-45840)
- PerCP (Cat. MA5-45842)
- Custom conjugation available upon request
Product Specific Information
- 1:1,000 dilution of MA5-45841 detects Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot using goat anti-mouse IgG:HRP as secondary antibody.
- Binds within the 101–130 aa region of human alpha synuclein (confirmed by Dot blot and ELISA).
- Detects ~14 kDa band (Alpha synuclein) and ~40 kDa trimer band.
- Does not detect truncated alpha Synuclein (aa 1–114).
Target Information
Alpha-synuclein belongs to the synuclein family (including beta- and gamma-synuclein). These proteins are abundant in the brain and regulate synaptic transmission and membrane trafficking.
Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting roles in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease.
Multiple alternatively spliced transcripts encoding different isoforms exist.
Associated diseases include Parkinson Disease 1 (Autosomal Dominant) and Lewy Body Dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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