Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (7E.17G9), Biotin, eBioscience

Applications

Tested Application

• Flow Cytometry (Flow)

Tested Dilution

• ≤ 0.06 µg/test

Publications

• View 11 publications

Product Specifications

Available Formats

• Unconjugated
• APC
• FITC
• Functional Grade
• PE
• PE-Cyanine5
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 645
• Request custom conjugation

Product Specific Information

The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell–specific molecule and a third member of the CD28/CTLA-4 family.
ICOS is a 47–57 kDa homodimer expressed on activated T cells and provides potent costimulatory activity for T cell activation and proliferation, essential for humoral immune response.
It binds to its ligand B7h/B7RP-1 on activated antigen-presenting cells, including B cells, and may play a protective role in inflammatory autoimmune diseases.
ICOS is also implicated in Th2 cell development.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested on unstimulated and Con A-stimulated (3-day) mouse splenocytes. Recommended ≤ 0.06 µg per test (100 µL final volume). Optimal titration required.

Target Information

ICOS (CD278) encodes a member of the CD28/CTLA-4 receptor family functioning as a homodimer. It plays a crucial role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Mutations or dysregulation of ICOS have been associated with immune disorders such as Common Variable Immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.