Thermo Fisher Scientific BID Monoclonal Antibody (OTI2B6), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:400–1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It is a member of the BCL-2 family of cell death regulators.
BID mediates mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the C-terminal fragment translocates to mitochondria, triggering cytochrome c release and apoptosis.
In living cells, BID exists in an inactive cytosolic form and becomes activated by TNFα or Fas ligand through caspase-8 cleavage. The resulting p15 fragment induces mitochondrial cytochrome c release, linking caspase activation to mitochondrial death pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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